|Protein folding diseases targets|
AB Vector provides recombinant baculovirus stocks for the expression of several proteins which are misfolded and accumulate in protein folding diseases.
Tau is a neuronal microtubule-associated protein which is a key component of neurofibrillary tangles in Alzheimer's disease. Filamentous tau deposits in neurons or glial cells are also characteristic for Pick's disease, corticobasal degeneration and progressive supranuclear palsy (Hasegawa, Neuropathology, 2006, 26:484-90).
Alpha-synuclein is a major component of proteinaceous aggregates associated with Parkinson's disease and other synucleopathies, such as Lewy body dementia, Lewy body variant of Alzheimer's disease, and multiple system atrophy (Beyer, Acta Neuropathol, 2006, 112:237-51).
SOD1 (Cu, Zn-superoxide dismutase) misfolding is causative to amyotropic lateral sclerosis (Rakhit and Chakrabartty, Biochim Biophys Acta, 2006, 1762: 1025-37).
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